Introducing RPACT
Where Statistical Innovation Meets Open Source Excellence
April 13, 2026
日本に戻って来れてうれしい! 🇯🇵
RPACT team: statistics and software engineering 💻
RPACT: Trusted by leading pharmaceutical companies
- Long-term collaborations with global pharmaceutical organizations
![RPACT customers (as of 2025)]()
- Productive use of our tools in research and regulated environments
- Trusted partner for statistical methodology, software, validation, and training
RPACT products: proven ecosystem
Service Level Agreement (SLA) based, custom feature development and license based collaborations:
rpact for fixed and adaptive clinical trials
crmPack supporting dose escalation trials
mmrm (just one example of many)
The rpact Package 📦
- Comprehensive, formally validated R package implementing methodology described in Wassmer and Brannath (2016)
- Enables the design of traditional and confirmatory adaptive group sequential designs
- Provides interim data analysis and simulation including early efficacy stopping and futility analyses
- Enables sample-size reassessment with different strategies
- Enables treatment arm selection in multi-stage multi-arm (MAMS) designs
- Enables subset selection in population enrichment designs
- Provides a comprehensive and reliable sample size calculator
The crmPack Package 📦
- R package for dose escalation trials initially released in 2016, highly flexible and easily extensible for a wide range of designs
- Facilitates trial analyses as well as simulations, allowing for the evaluation of various scenarios and assess the performance of different dose escalation strategies
- Produces plots and summaries, enabling clear and intuitive presentation of trial results
- Paper published in 2019 (link)
- Open source team started collaborating since 2021 (Bayer, Merck, Roche, Cambridge University) (slides)
- SLA-based support and custom feature development started in October 2025 (backfill cohort simulation, currently working on two drug combination designs, next will be validation documentation)
RPACT Cloud ☁️
- Professional graphical user interface based on R/Shiny for
rpact - Web based usage without local installation on nearly any device
- Provides an easy entry to
rpactin a user friendly and intuitive way and allows to create reports - Free demo version online available at rpact.cloud
- In 2025, 4 major pharmaceutical companies have licensed RPACT Cloud for internal installation and use on their own servers - fully replacing previous proprietary software
- We support them with extensive documentation covering setup on Posit Connect, configuration, and full qualification/validation
Open source with a long-term commitment
- Open source as a strategic choice, not an experiment
- Clear focus on sustainability, validation, and maintainability
- Reduction of complexity in daily statistical workflows
- Professional governance with service level agreement-backed responsibility
- Continuous evolution driven by real-world user needs
- Synergy with LLM-based coding tools due to open source
RPACT visits Japan: Let’s connect! 🤝
- I am looking forward to meeting you today and connecting with you!
- I am curious about:
- Your current challenges and experience with R and open source tools in your work
- Your ideas how RPACT could support you and your organization in the future
- I still have free time - let’s arrange a meeting! 😄
- in the morning of 15th April here in Tokyo,
- as well as morning of 16th April in Osaka
- No time this week? No problem, you can book an online meeting slot here!
You can reach me at daniel@rconis.com
Executive summary 📝
- Trusted long-term partner for leading pharmaceutical organizations
- Service level agreements for
rpactandcrmPack, licenses for RPACT Cloud - Custom feature and package development
- Coming 2026: RPACT Code AI assistant
- Service level agreements for
- High user adoption through usability-focused packages and graphical user interfaces
- Lean expert organization with clear ownership and long-term commitment, combining methodology, software, and validation expertise
- Proven training expertise with online and on-site formats, tailored to customer needs
RPACT: Where Statistical Innovation Meets Open Source Excellence
RCONIS: a joint venture brand 🤝
- RCONIS (Research Consulting and Innovative Solutions) is brand of RPACT, not a formal company
- RCONIS is the brand umbrella for RPACT (rpact.com) and inferential.biostatistics (inferential.bio)
- Statistical consulting and engineering services:
Research Consulting and Innovative Solutions - Website: rconis.com
